The following new article have just been published in Asthma Research and Practice: Exhaled biomarkers in childhood asthma: old and new approaches

Review - Open Access
 
Valentina Ferraro, Silvia CarraroSara BozzettoStefania Zanconato and Eugenio Baraldi
 

Abstract

Background

Asthma is a chronic condition usually characterized by underlying inflammation. The study of asthmatic inflammation is of the utmost importance for both diagnostic and monitoring purposes. The gold standard for investigating airway inflammation is bronchoscopy, with bronchoalveolar lavage and bronchial biopsy, but the invasiveness of such procedures limits their use in children. For this reason, in the last decades there has been a growing interest for the development of noninvasive methods.

Main body

In the present review, we describe the most important non-invasive methods for the study of airway inflammation in children, focusing on the measure of the fractional exhaled nitric oxide (feNO), on the measure of the exhaled breath temperature (EBT) and on the analysis of both exhaled breath condensate (EBC) and exhaled air (Volatile Organic Compounds, VOCs), using targeted and untargeted approaches. We summarize what is currently known on the topic of exhaled biomarkers in childhood asthma, with a special emphasis on emerging approaches, underlining the role of exhaled biomarkers in the diagnosis, management and treatment of asthma, and their potential for the development of personalized treatments.

Conclusion

Among non-invasive methods to study asthma, exhaled breath analysis remains one of the most interesting approaches, feNO and “-omic” sciences seem promising for the purpose of characterizing biomarkers of this disease.

Download PDF

 

 

 

(You must be logged in to add and reply comments)

Interasma on Twitter

Interasma Top story: RSVP to the Back-to-School Twitter Party https://t.co/kfgS8pRncS, see more https://t.co/CpGiFuOOYd
10hreplyretweetfavorite
Interasma Top story: Three Common Comorbidities With Asthma https://t.co/UfB8hfM3H4, see more https://t.co/CpGiFuOOYd
12hreplyretweetfavorite
Interasma RT @ARIAGuideline: This article summarizes a EUFOREA symposium, presented during the European Rhinology Research Forum in Brussels (9-10 No…
18hreplyretweetfavorite
Interasma RT @ARIAGuideline: Rhinology future trends: 2017 EUFOREA debate on allergic rhinitis. https://t.co/ZMAchhHdBx
18hreplyretweetfavorite

Editor: Juan C. Ivancevich, MD

Copyright © Interasma 2003-2017  •  Terms of Use  •  Privacy Policy  •  Contact Us  •  Sitemap

Powered by FREI SA

InterAsma