Letter to the Editors 
Open Access
Open AccessAllergy Asthma Immunol Res. 2016 Jan;8(1):84-85. English.
http://dx.doi.org/10.4168/aair.2016.8.1.84
http://dx.doi.org/10.4168/aair.2016.8.1.84
Maria Angela Tosca,1 Michela Silvestri,1 Nicoletta Solari,1 Giovanni Arturo Rossi,1 and Giorgio Ciprandi
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2Jang and colleagues investigated the relationship between exhaled nitric oxide (FeNO) and atopy profiles in children with asthma.1 They focused their attention mainly on the FeNO, showing that this parameter varied according to the profile of atopy. The authors also investigated lung function, including bronchial hyperreactivity. However, forced vital capacity, forced expiratory volume in 1 second (FEV1), and their ratio were considered as parameters for lung function test. On the other hand, great attention has been recently paid to the relevance in asthma pathogenesis of FEF25-75 values,2 a parameter considered to better reflect small airways than the gold standard parameters of airway obstruction, such as forced vital capacity and FEV1.2 This may be even more relevant in childhood.3 Indeed, in allergic children with asthma, impaired FEF25-75values appear to be related to severe bronchial hyperreactivity,4 reversible airway obstruction;5 perception of breathlessness and of positive response to reversibility test, assessed by visual analogue scale.6, 7
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