Jakwerth CA, Weckmann M, Illi S et al. 17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma. Am J Respir Crit Care Med. 2023 Dec 8. doi: 10.1164/rccm.202305-0934OC. Abstract Rationale: The…
J Exp Med (2024) 221 (6): e20231236. Abstract: Epithelium-derived cytokines or alarmins, such as interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP), are major players in type 2 immunity and asthma. Here,…
Richard J. Russell, Louis-Philippe Boulet, Christopher E. Brightling et al. European Respiratory Journal 2024 63: 2301397; DOI: 10.1183/13993003.01397-2023 Abstract Asthma is a disease of heterogeneous pathology, typically characterised by excessive inflammatory and bronchoconstrictor responses to the environment. The clinical expression…
Bourdin A, Brusselle G, Couillard S et al. J Allergy Clin Immunol Pract. 2024 Jan 25:S2213-2198(24)00075-8. doi: 10.1016/j.jaip.2024.01.023. Abstract: Severe asthma is associated with significant morbidity and mortality despite the…
Bagley DC, Russell T, Ortiz-Zapater E, Stinson S, Fox K, Redd PF, Joseph M, Deering-Rice C, Reilly C, Parsons M, Brightling C, Rosenblatt J. Bronchoconstriction damages airway epithelia by crowding-induced…
Shusterman D. Front Allergy. 2024 Mar 12;5:1374771. doi: 10.3389/falgy.2024.1374771. Abstract Combined exposures to allergens and air pollutants emerged as a topic of concern in scientific circles by the 1980’s, when…
Kelly A, Lavender P. Allergy Asthma Immunol Res. 2024 Mar;16(2):130-141. https://doi.org/10.4168/aair.2024.16.2.130 Abstract The prevalence of asthma escalated rapidly in the late 20th century. In 2019, the World Health Organization estimated…
Zerr, B.A., Kruse, J.M. & Glover, J.J. Allergy Asthma Clin Immunol 20, 27 (2024). https://doi.org/10.1186/s13223-024-00888-6 Abstract Background A significant update was made to both the Global Initiative for Asthma (GINA) in…
Benjamin P. Hurrell, Stephen Shen, Xin Li, Yoshihiro Sakano, Mohammad Hossein Kazemi, Christine Quach, Pedram Shafiei-Jahani, Kei Sakano, Homayon Ghiasi, Omid Akbari. J Exp Med 6 May 2024; 221 (5):…
Hsu, YT., Wu, CC., Wang, CC. et al. Respir Res 25, 139 (2024). https://doi.org/10.1186/s12931-024-02764-8 Abstract Background DEHP, a common plasticizer known for its hormone-disrupting properties, has been associated with asthma. However, a significant…