This new issue contains the following articles:

Mechanisms

Urinary caffeine and caffeine metabolites, asthma, and lung function in a nationwide study of U.S. adults
Yueh-Ying Han , PhD, Erick Forno MD, MPH & Juan C. Celedón MD, DrPH
Pages: 2127-2134 | DOI: 10.1080/02770903.2021.1993250

Serum IFNγ–induced protein 10 (IP10/CXCL10): association with asthma exacerbations and severity in children
Hanan M. Osman MD, Noussa Ragab El Basha MD, Ahmed F. Mansour MSc & Mariam Onsy F. Hanna MD
Pages: 2135-2142 | DOI: 10.1080/02770903.2021.1999465

Association between early childhood lower respiratory tract infections and subsequent asthma
Mark S. Brittan, MD, MPH, Angela Moss, MS, John D. Watson, MD, Monica J. Federico, MD, John D. Rice, PhD, Amanda F. Dempsey, MD, MPH & Lilliam Ambroggio, MPH, PhD
Pages: 2143-2153 | DOI: 10.1080/02770903.2021.1999469

Alterations of serum and saliva oxidative markers in patients with bronchial asthma
Muayad M. Abboud PhD, Futoon A. Al-Rawashde PhD & Enas M. Al-Zayadneh MD (Pediatrics)
Pages: 2154-2161 | DOI: 10.1080/02770903.2021.2008426

Pharmacotherapy

Cost-effectiveness analysis of dupilumab among patients with oral corticosteroid-dependent uncontrolled severe asthma in Japan | 
Yuji Tohda, MD, PhD, Hisako Matsumoto, MD, PhD, Masanori Miyata, PhD, Yurie Taguchi, PhD, MBA, Maki Ueyama, PhD, MPA, Florence Joulain, MSc & Ichiro Arakawa, PhD
Pages: 2162-2173 | DOI: 10.1080/02770903.2021.1996596

The course of COVID-19 in patients with severe asthma receiving biological treatment
Gülseren Tuncay, MD, Mehmet Erdem Cakmak, MD, Ozge Can Bostan, MD, Saltuk Bugra Kaya, MD, Ebru Damadoglu, MD, Gül Karakaya, MD & Ali Fuat Kalyoncu, MD
Pages: 2174-2180 | DOI: 10.1080/02770903.2021.1996599

Acute asthma management with IV magnesium in obese, overweight and non-overweight inner-city children
Audrey Uong MD, MS, Patricia Hametz MD, MPH, Denzel Zhu BS, Adam Kopp MD & Karen Warman MD, MS
Pages: 2181-2188 | DOI: 10.1080/02770903.2021.2008425

Use of inhaled corticosteroids on an intermittent or as-needed basis in pediatric asthma: a systematic review of the literature
Carlos E. Rodriguez-Martinez, MD, MSC, PhD, Monica P. Sossa-Briceño, MD, MSC & Luis Garcia-Marcos, MD
Pages: 2189-2200 | DOI: 10.1080/02770903.2021.2008430

Real-life effectiveness of mepolizumab in severe asthma: a systematic literature review | 
Elliot Israel, MD, Giorgio Walter Canonica, MD, Guy Brusselle, MD, PhD, Shibing Yang, PhD, Peter H. Howarth, MD, PhD, Amber L. Martin, PhD, Maria Koufopoulou, PhD, Steven G. Smith, PhD & Rafael Alfonso-Cristancho, MD, PhD
Pages: 2201-2217 | DOI: 10.1080/02770903.2021.2008431

Safety of biological therapy in elderly patients with severe asthma
Patricia Mir-Ihara, MD, Emilio Narváez-Fernández, MD, Javier Domínguez-Ortega, MD, PhD, Ana Entrala, MD, Pilar Barranco, MD, PhD, Juan-Alberto Luna-Porta, MD, David Romero, MD, PhD, Elena Villamañán, PharmD, PhD, Itsaso Losantos-García BMath & Santiago Quirce, MD, PhD
Pages: 2218-2222 | DOI: 10.1080/02770903.2021.2010747

Pediatric Asthma

Small airways targeted treatment with smart nebulizer technology could improve severe asthma in children: a retrospective analysis | 
Wytse B. van den Bosch, MD, Sanne F. Kloosterman, MD, Eleni-Rosalina Andrinopoulou, PhD, Rients Greidanus, BSc, Mariëlle W. H. Pijnenburg, MD, PhD, Harm A. W. M. Tiddens, MD, PhD & Hettie M. Janssens, MD, PhD
Pages: 2223-2233 | DOI: 10.1080/02770903.2021.1996597

Psychosocial factors and lack of asthma knowledge undermine child and adolescent adherence to inhaled corticosteroid
P. Takkinsatian, MD, S. Chantaratin, MD, S. Sirisakpanit, MSc (clinical psychology), W. Srisuwatchari, MD, P. Pacharn, MD, O. Jirapongsananuruk, MD & N. Visitsunthorn, MD
Pages: 2234-2245 | DOI: 10.1080/02770903.2021.1999468

Impact of caregiver depression on child asthma outcomes in Mexicans and Puerto Ricans
Karenjot Kaur, PhD, Kimberly J. Arcoleo, PhD, MPH, Denise Serebrisky, MD, Deepa Rastogi, MBBS, MS, Flavio F. Marsiglia, PhD & Jonathan M. Feldman, PhD
Pages: 2246-2257 | DOI: 10.1080/02770903.2021.2008427

Improved 10-year cost savings for patients served by the Boston Children’s Hospital Community Asthma Initiative
Elizabeth R. Woods, MD, MPH, Susan J. Sommer, MSN, WHNP-BC, AE-C, Emily A. Bryson, BS, Kyra M. Shreeve, BS, Dionne Graham, PhD, Shari Nethersole, MD & Urmi Bhaumik, MBBS, MS, ScD
Pages: 2258-2266 | DOI: 10.1080/02770903.2021.2010746

Biomarkers

Obese, non-eosinophilic asthma: frequent exacerbators in a real-world setting
Sachin Ananth, MD, Alessio Navarra, MD & Rama Vancheeswaran, MD, PhD
Pages: 2267-2275 | DOI: 10.1080/02770903.2021.1996598
Diagnostics

Early diagnosis of aspergillosis in asthmatic and rheumatoid arthritis patients by Aspergillus galactomannan antigen assay: a case-control study in Karbala providence
Ali Abdul Hussein S. Al-Janabi PhD & Roaa Noori Ali MSc
Pages: 2276-2282 | DOI: 10.1080/02770903.2021.1996601

Asthma Outcomes

Characteristics and outcomes associated with two asthma quality of care measures
Justin Blackburn PhD, Pradeep Sharma MS, MBA, Ye Liu BS, Michael A. Morrisey PhD, Nir Menachemi PhD, MPH, Bisakha Sen PhD, Teela Sanders JD & David J. Becker PhD
Pages: 2283-2291 | DOI: 10.1080/02770903.2021.1996602

Effects of high intensity interval training and sprint interval training in patients with asthma: a systematic review
Gamze Ertürk, MSc, PT, Çiçek Günday, MSc, PT, Halenur Evrendilek, MSc, PT, Kübra Sağır, MSc, PT & Gökşen Kuran Aslan, PT
Pages: 2292-2304 | DOI: 10.1080/02770903.2021.1999470

Psychometric properties of two instruments measuring self-efficacy and outcome expectations of providing inhaler technique education to patients
Chris Gillette, PhD, Nicole Ludwig, MSPA, PA-C, Gayle Bodner, MMS, PA-C, Caroline Grey Bell Sisson, MMS, PA-C, Courtney J. Perry, PharmD, Andrea McKinnond, MMS, PA-C, Kristin Lindaman, MMS, PA-C & Charles T. Jensen, MMS, PA-C
Pages: 2305-2313 | DOI: 10.1080/02770903.2021.2008428

Asthma is not a risk factor for severity of SARS-CoV-2 infection in the Mexican population
Jaime Morales-Romero MD, PhD & Martín Bedolla-Barajas MD, MSc
Pages: 2314-2321 | DOI: 10.1080/02770903.2021.2010745

Enviromental Determinants

Outdoor air pollution and the risk of asthma exacerbations in single lag0 and lag1 exposure patterns: a systematic review and meta-analysis | 
Junjun Huang, MD, Xiaoyu Yang, MM, Fangfang Fan MD, Yan Hu, MD, Xi Wang, MD, Sainan Zhu, MM, Guanhua Ren, MM & Guangfa Wang, MD
Pages: 2322-2339 | DOI: 10.1080/02770903.2021.2008429