Jesenak M, Bobcakova DA, Djukanovic R, Gaga M, Hanania NA, Heaney LG, Pavord I, Quirce S, Ryan DD, Fokkens W, Conti DD, Hellings PW, Scadding G, Van Staeyen E, Bjermer LH, Diamant Z. Chest. 2024 Dec 11:S0012-3692(24)05617-4. doi: 10.1016/j.chest.2024.11.035.
Abstract
Topic importance
Asthma is a common multifaceted respiratory disease with a major impact on quality of life. Despite increased insights into mechanisms underlying various asthma phenotypes/endotypes and the availability of targeted biologic treatment options, a substantial proportion of patients remains uncontrolled with risk of exacerbations, requiring systemic corticosteroids, and progressive disease.
Current international guidelines advocate a personalized management approach to patients with uncontrolled severe asthma.
Review findings
The EUFOREA asthma expert panel was convened to discuss strategies to optimize asthma care, prevent systemic corticosteroids overuse and disease progression. In this meeting report, we summarize current concepts and recommendations and provide a rationale to implement personalized asthma management at earlier stages of the disease. The ultimate goal is to move away from the current “one-size-fits-most” concept, which focuses on a symptom-driven treatment strategy, and shift towards a phenotype/endotype-targeted approach aimed at curbing the disease course by improving clinical outcomes and preserving health-related quality of life.