Asthma – how new medicines and services are improving lives?
Asthma affects up to one in ten of the population and the NHS spends around £1bn annually on treatments. Whether you’re a concerned parent of a wheezy toddler, a teenager…
PI3Kγδ inhibition suppresses key disease features in a rat model of asthma
Pinkerton, J.W., Preite, S., Piras, A. et al. Respir Res 25, 175 (2024). https://doi.org/10.1186/s12931-024-02814-1 Abstract Background Two isoforms of Phosphoinositide 3-kinase (PI3K), p110γ and p110δ, are predominantly expressed in leukocytes and represent attractive…
Elevated Saliva Pepsin Concentration as a Risk Factor for Asthma in Children with Allergic Rhinitis: A Preliminary Study
Sui H, Shen H, Zhang C, Wang M, Zhen Z, Zhang J. J Asthma Allergy. 2024;17:391-397https://doi.org/10.2147/JAA.S447145 Abstract: Objective: This study aimed to explore whether saliva pepsin concentration (SPC) could be regarded as…
Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma.
Wechsler ME, Scelo G, Larenas-Linnemann DES et al. Am J Respir Crit Care Med. 2024 Feb 1;209(3):262-272. doi: 10.1164/rccm.202305-0808OC. Abstract Rationale: Previous studies investigating the impact of comorbidities on the effectiveness…
A survey of severe asthma in Canada: results from the CASCADE practice reflective program
Research – Open access Krystelle Godbout, Harold Kim, Irvin Mayers, James Paterson & Charles K. N. Chan Allergy, Asthma & Clinical Immunology volume 20, Article number: 31 (2024) Abstract Background Since the last guidance was published by the Canadian Thoracic…
17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma
Jakwerth CA, Weckmann M, Illi S et al. 17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma. Am J Respir Crit Care Med. 2023 Dec 8. doi: 10.1164/rccm.202305-0934OC. Abstract Rationale: The…
TL1A is an epithelial alarmin that cooperates with IL-33 for initiation of allergic airway inflammation
J Exp Med (2024) 221 (6): e20231236. Abstract: Epithelium-derived cytokines or alarmins, such as interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP), are major players in type 2 immunity and asthma. Here,…
The airway epithelium: an orchestrator of inflammation, a key structural barrier and a therapeutic target in severe asthma
Richard J. Russell, Louis-Philippe Boulet, Christopher E. Brightling et al. European Respiratory Journal 2024 63: 2301397; DOI: 10.1183/13993003.01397-2023 Abstract Asthma is a disease of heterogeneous pathology, typically characterised by excessive inflammatory and bronchoconstrictor responses to the environment. The clinical expression…
Phenotyping of Severe Asthma in the Era of Broad-Acting Anti-asthma Biologics
Bourdin A, Brusselle G, Couillard S et al. J Allergy Clin Immunol Pract. 2024 Jan 25:S2213-2198(24)00075-8. doi: 10.1016/j.jaip.2024.01.023. Abstract: Severe asthma is associated with significant morbidity and mortality despite the…
Bronchoconstriction damages airway epithelia by crowding-induced excess cell extrusion
Bagley DC, Russell T, Ortiz-Zapater E, Stinson S, Fox K, Redd PF, Joseph M, Deering-Rice C, Reilly C, Parsons M, Brightling C, Rosenblatt J. Bronchoconstriction damages airway epithelia by crowding-induced…