Raised sputum extracellular DNA confers lung function impairment and poor symptom control in an exacerbation-susceptible phenotype of neutrophilic asthma
Research – Open Access Mustafa Abdo, Mohib Uddin, Torsten Goldmann, Sebastian Marwitz, Thomas Bahmer, Olaf Holz, Anne-Marie Kirsten, Frederik Trinkmann, Erika von Mutius, Matthias Kopp, Gesine Hansen, Klaus F. Rabe, Henrik Watz, Frauke Pedersen on behalf of the ALLIANCE study group Respiratory Research volume 22, Article number: 167 (2021) Abstract…
Association between prevalence of obstructive lung disease and obesity: results from The Vermont Diabetes Information System
Research Open Access Maria E. Ramos-Nino, Charles D. MacLean & Benjamin Littenberg Asthma Research and Practice volume 7, Article number: 6 (2021) Abstract Background The association of obesity with the development of obstructive lung disease, namely asthma and/or…
RORγt inhibitors block both IL-17 and IL-22 conferring a potential advantage over anti-IL-17 alone to treat severe asthma
Research – Open Access David Lamb, Dorothy De Sousa, Karsten Quast, Katrin Fundel-Clemens, Jonas S. Erjefält, Caroline Sandén, Hans Jürgen Hoffmann, Marc Kästle, Ramona Schmid, Kevin Menden & Denis Delic Respiratory Research volume 22, Article number: 158 (2021) Abstract Background RORγt is a transcription factor that…
Tezepelumab Biologics License Application Submitted for Severe Asthma
Brian Park, PharmD The Biologics License Application (BLA) for tezepelumab has been submitted to the Food and Drug Administration (FDA) for patients with severe asthma. Tezepelumab is an investigational first-in-class…
Characteristics of inflammatory phenotypes among patients with asthma: relationships of blood count parameters with sputum cellular phenotypes
Research – Open Access Bingqing Shi, Wei Li, Yuqiu Hao, Hongna Dong, Wenjing Cao, Jie Guo & Peng Gao Allergy, Asthma & Clinical Immunology volume 17, Article number: 47 (2021) Abstract Background There is a need to identify the asthma inflammatory phenotypes…
2021 update of the Global Strategy for Asthma Management and Prevention
The 2021 update of the Global Strategy for Asthma Management and Prevention incorporates new scientific information about asthma based on a review of recent scientific literature by an international panel…
Differential Gene Expressions in Cough Variant Asthma and Classical Asthma
Virginia A. Schad, PharmD, RPh The pathogenesis of cough variant asthma and classical asthma may be related to genes such as FCER1A, HDC, and IL4, according to study results published in the Journal of…
American Lung Association Report Shows 40% of US Regularly Breathes Polluted Air
Brandon May The American Lung Association’s (ALA) 22nd annual “State of the Air” report shows that approximately 135 million people in the United States — or, 4 in 10 Americans…
WORLD ASTHMA DAY 2021
Uncovering Asthma Misconceptions World Asthma Day (WAD) (May 5, 2021) is organized by the Global Initiative for Asthma, (GINA) (www.ginasthma.org), a World Health Organization collaborative organization founded in 1993. WAD…